A new break in V(D)J recombination
نویسندگان
چکیده
منابع مشابه
VDJ Recombination
Artemis is the newest player in VDJ recombination and double strand break repair. First identified in radiation-sensitive and immune-deficient patients, it was recently shown to interact with DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and have nuclease activity, becoming the most popular candidate for the opening of hairpin coding ends. Reports presented in this issue (1) and in ...
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ment, producing two coding ends and two signal ends. Howard Hughes Medical Institute Subsequent joiningof thecoding ends, forming a coding Baylor College of Medicine joint, assembles a rearranged TCR or Ig gene segment; Houston, Texas 77030 the signal ends also join, forming a signal joint. †Department of Molecular Biology and Genetics Several features of VDJ recombination are reminisHoward Hug...
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Currently five polymerases have been identified in Escherichia coli, at least eight in Saccharo‐ myces cerevisiae, nine in Schizosaccharomyces pombe, and fourteen in humans [1-4]. Based on the primary structure of the catalytic subunits, DNA polymerases have been classified into different families. Eukaryotic organisms have four families: A family (Polγ, Polθ and Polν), B family (Polα, Polδ, Po...
متن کاملAllelic exclusion of IgH through inhibition of E2A in a VDJ recombination complex.
A key feature of the immune system is the paradigm that one lymphocyte has only one Ag specificity that can be selected for or against. This requires that only one of the alleles of genes for AgR chains is made functional. However, the molecular mechanism of this allelic exclusion has been an enigma. In this study, we show that B lymphocytes with E2A that cannot be inhibited by calmodulin are d...
متن کاملVDJ Recombination: Artemis and Its In Vivo Role in Hairpin Opening
Artemis is the newest player in VDJ recombination and double strand break repair. First identified in radiation-sensitive and immune-deficient patients, it was recently shown to interact with DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and have nuclease activity, becoming the most popular candidate for the opening of hairpin coding ends. Reports presented in this issue (1) and in ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 1993
ISSN: 0960-9822
DOI: 10.1016/0960-9822(93)90150-m